A Case Study of Successful Ayurveda Management in the Patient of Migraine (Ardhavabhedaka) and Motion Sickness

Migraine is a type of Headache characterized by moderate to severe throbbing pain, generally associated with nausea, vomiting and light sensitivity. It can be correlated to Ardhavbhedaka, which according to the Ayurvedic science is caused by simultaneous vitiation of all the three Doshas viz. Vata, Pitta and Kapha. Motion sickness is also a common disorder wherein patient suffers from symptoms like nausea, vomiting, increased salivation, dizziness, upon getting triggered by certain movements. In this case study, a female patient of middle age group (Madhyam Avastha) suffering from long standing migraine and motion sickness since past 15 years (on and off), hampering her day to day activities, was administered with the treatment protocol as per Ayurveda resulting in significant relief to her symptoms. The treatment, planned according to her pulse diagnosis and clinical examination, was based on herbal supplements, Panchakarma (detoxification) in the form of Virechana, home remedies, Marmaa therapy, dietary and lifestyle modifications. The treatment was focused on removing the toxins (Aam) from the body with the help of detox (Virechana). This also resulted in alleviation of the vitiated Vata and Pitta Doshas and restoration of the Jatharagni (digestive fire). The treatment modality has been effective to reduce the episodes significantly.

Avaliação do desconforto sensorial causado por estimulação com realidade virtual em voluntários com e sem cinetose / Evaluation of sensory discomfort caused by stimulation with virtual reality in volunteers with and without kinetosis

RESUMO Objetivo comparar os sintomas da cinetose provocados por estímulo de realidade virtual, em voluntários com e sem histórico da doença. Métodos estudo analítico qualitativo e quantitativo, observacional transversal, prospectivo, realizado com voluntários com e sem histórico de cinetose, submetidos à imersão em realidade virtual com o uso de óculos de realidade aumentada. Antes e após a estimulação sensorial, o participante tinha a frequência respiratória (FR), a frequência cardíaca (FC) e pressão arterial sistólica (PAs) e diastólica (PAd) medidas. No primeiro dia, o voluntário foi exposto a um vídeo que simulava uma pessoa dentro de um carro, com predomínio de fluxo visual lateral. Após uma semana, uma animação de montanha russa, com predomínio de fluxo visual frontal. Durante a estimulação sensorial de dez minutos, uma nota de 0 a 10 era dada a cada 30 segundos para a intensidade do desconforto sentido pelo participante. Após, um questionário foi realizado para avaliação dos sintomas de cinetose. Resultados indivíduos com cinetose apresentaram maior intensidade de sintomas, tanto no experimento do carro (p=0,026), como na montanha russa (p=0,035). Não houve correlação entre cinetose e as variáveis FC, FR e PA. Os pacientes com cinetose atribuíram maiores notas de desconforto no curso das experiências, principalmente na experiência da montanha russa. Conclusão indivíduos com cinetose apresentam sintomas mais intensos quando submetidos a estímulos por realidade virtual, se comparados a indivíduos sem a doença.

ABSCTRACT Purpose to compare the symptoms of motion sickness caused by virtual reality stimulation in volunteers with and without history of the disease. Methods qualitative and analytical, observational, cross-sectional, and prospective study, approved by Research Ethics Committee, 3.443.429/19, with volunteers with and without history of motion sickness who were subjected to immersion in VR with the use of virtual reality glasses. Before and after sensory stimulation, the participant had respiratory rate (RF), heart rate (HR) and systolic blood pressure (PAs) and diastolic blood pressure (PAd) measured. On the first day, the volunteer was exposed to a video that simulated a person in a car, with a predominance of lateral visual flow. A week later, an animation of a roller coaster, with a predominance of frontal visual flow. During the 10-minute experiment, a score from 0 to 10 was given every 30 seconds for the intensity of the discomfort felt by the volunteer. A post-questionnaire was conducted to assess motion sickness symptoms. Results individuals with motion sickness history had a higher intensity of symptoms in the car (p = 0.026) and roller coaster experiment (p = 0.035). There was no correlation between motion sickness and the variables HR,FR,PA. Patients with motion sickness gave higher scores of discomfort throughout the experiments, mainly in the roller coaster experience. Conclusion individuals with motion sickness present more intense symptoms when subjected to stimuli by VR compared to controls without disease.

Comparison of clinical characteristics and vestibular function test results in patients with vestibular migraine and Menière's disease

Abstract Objectives The differentiation between Vestibular Migraine (VM) and Meniere's Disease (MD) is difficult because of overlapping symptoms. The study aimed to compare the clinical characteristics and vestibular function test results between VM and MD patients. Methods Seventy-one patients with definite VM and 31 patients with definite unilateral MD were included. All patients received Caloric Test (CT), Video Head Impulse Test (vHIT) and Vestibular Evoked Myogenic Potential (VEMP) test within 7 days after visiting the hospital. Results of these tests were compared between groups. Results Most VM patients (64.0%) experienced spontaneous internal vertigo, while most MD patients (66.7%) experienced spontaneous external vertigo. MD patients had more severe vestibular symptoms and autonomic responses compared to VM patients during attacks (p= 0.03, p= 0.00, respectively). The nystagmus intensity of CT-induced was greater in VM patients than in MD patients (p= 0.003). More VM patients had CT intolerance and Central Positional Nystagmus (CPN) compared to MD patients (p= 0.002, p = 0.006, respectively). More MD patients had CT(+) and vHIT saccades wave compared to VM patients (p< 0.001, p= 0.002, respectively). The non-elicitation rate of cervical VEMP was higher, and the ocular VEMP amplitudes were lower in MD patients than in VM patients (p = 0.002, p= 0.018). Conclusions Vestibular symptoms during attacks combined with the results of vestibular function tests may be used to differentiate between VM and MD. The diverse nature of vestibular symptoms (especially internal vertigo), history of motion sickness and CT intolerance may provide clues to the diagnosis of VM, whereas spontaneous external vertigo, CT(+) with vHIT(-), and the presence of saccades may provide clues to the diagnosis of MD. Level of evidence: 4.

Adaptación transcultural del cuestionario motion sickness susceptibility questionnaire form short (MSSQ-SHORT) para la población adulta chilena / Cross-cultural adaptation of the motion sickness susceptibility questionnaire form short (MSSQ-SHORT) for the chilean adult population

Resumen Introducción: La cinetosis se relaciona con la presencia de una serie de síntomas que comúnmente son inducidos por situaciones cotidianas de viajes en medios de transporte. Una forma utilizada por décadas para determinar el grado de susceptibilidad a la cinetosis ha sido con la aplicación del cuestionario en su versión acortada Motion Sickness Suscep-tibility-short (MSSQ-short). Objetivo: Adaptar lingüística y transculturalmente al español el cuestionario MSSQ-short. Material y Método: Se llevaron a cabo cuatro etapas: Traducción directa, traducción inversa (retrotraducción), consolidación por un comité de expertos y pretest (aplicabilidad/viabilidad). En la etapa de pre-test 51 personas respondieron el cuestionario. Resultados: La discrepancias encontradas en las primeras etapas fueron resueltas por un tercer traductor, el cual concluyó en un documento final en español que fue analizado y revisado por el comité de expertos. Se determinaron los percentiles del 0 al 100, percentil 50 con 9,0 puntos, percentil 25 con 2,13 puntos y el percentil 75 con 17,4 puntos. La consistencia interna del cuestionario fue de 0,889. Conclusión: La traducción y adaptación transcultural fue aceptada por un comité de expertos y participantes con distintas características demográficas y educacionales. El cuestionario obtuvo buena consistencia interna y resultados concordantes con la versión original.

Abstract Introduction: Motion sickness is related to the presence of a series of symptoms that are typically induced by everyday situations of travel in means of transport. A way used for decades to determine the degree of susceptibility to motion sickness has been with the application of the questionnaire in its shortened version Motion Sickness Susceptibility-short (MSSQ-short). Aim: Linguistically and cross-culturally adapt the MSSQ-short questionnaire to Spanish. Material and Method: Four stages were carried out: direct translation, reverse translation (back translation), consolidation by a committee of experts, and pretest (applicability/feasibility). In the pre-test stage, 51 people answered the questionnaire. Results: The discrepancies found in the early stages were resolved by a third translator, which concluded in a final document in Spanish that was analyzed and reviewed by the expert committee. The percentiles from 0 to 100 were determined, 50th percentile with 9.0 points, 25th percentile with 2.13 points, and 75th percentile with 17.4 points. The internal consistency of the questionnaire was 0.889. Conclusion: The cross-cultural translation and adaptation were accepted by a committee of experts and participants with different demographic and educational characteristics. The questionnaire obtained good internal consistency and results consistent with the original version.

Advances in prevention and treatment for motion sickness / 药学实践杂志

Motion sickness is a series of physiological responses in human being caused by abnormal movement stimulation. With the development of science and technology, a growing number of people choose to travel by high speed vehicles. Motion sickness happens more frequently. A large number of non-drug and drug intervention methods have been reported in the treatment of motion sickness. This article provides an overview on the research developments in the prevention and treatment of motion sickness in order to provide new ideas for drug research.

Suscetibilidade à cinetose em crianças de oito a onze anos / Susceptibilidad al cinetosis en niños de 8 a 12 años de edad / Susceptibility to motion sickness in children from eight to eleven years of age

RESUMO A cinetose se caracteriza pela intolerância ao movimento, resultante de um conflito sensorial entre os sistemas visual, proprioceptivo e vestibular. Na população infantil, a cinetose é frequente, porém o difícil diagnóstico acaba subestimando a prevalência nesse grupo específico. As alterações vestibulares pediátricas têm importante influência no desenvolvimento infantil. O objetivo do artigo foi analisar a suscetibilidade à cinetose em crianças e verificar possíveis fatores associados, bem como identificar diferenças entre as respostas, quando comparados os sexos, as faixas etárias e a autopercepção dos pais. Trata-se de um estudo transversal. A amostra de conveniência consecutiva foi constituída por crianças de ambos os sexos, com idade entre oito e onze anos. Para avaliar a suscetibilidade à cinetose, foi aplicado o motion sickness questionnaire short form (MSSQ), realizado individualmente com cada criança. A análise estatística foi realizada por meio do SPSS Versão v.21. Adotou-se nível de significância de 0,05. Utilizaram-se os testes estatísticos Kolmogorov-Smirnov; T de Student; Anova e teste de Friedman. Ao total, foram analisadas 223 crianças. Observou-se que 89,7% das crianças avaliadas eram suscetíveis à cinetose. Houve diferença significativa na comparação da suscetibilidade à cinetose entre os sexos, sendo as meninas, mais suscetíveis em relação aos meninos (p=0,001). Na comparação entre as faixas etárias, não houve significância estatística. Crianças com onze anos apresentaram maior suscetibilidade à cinetose. Houve diferença nas respostas relatadas pelas crianças e pais sobre a suscetibilidade das crianças à cinetose.

RESUMEN El cinetosis es la intolerancia al movimiento pasivo, resultado de un conflicto sensorial entre los sistemas visual, propioceptivo y vestibular. La población infantil padece con frecuencia del cinetosis, pero su prevalencia se subestima debido al difícil diagnóstico en este grupo específico. Los trastornos vestibulares en niños influyen significativamente en su desarrollo. El objetivo de este artículo fue analizar la susceptibilidad al cinetosis en niños y sus factores asociados, así como identificar las diferencias entre las respuestas en la comparación entre los sexos, los grupos de edad y la autopercepción de los padres. Se trata de un estudio transversal. La muestra de conveniencia consecutiva estuvo compuesta de niños de ambos sexos, con edades comprendidas entre 8 y 12 años. Para evaluar la susceptibilidad al cinetosis, se aplicó el motion sickness questionnaire short form (MSSQ) de manera individual en cada niño. Para el análisis estadístico se utilizó el software SPSS, versión 21.0. El nivel de significancia adoptado fue de 0,05. Se utilizaron pruebas estadísticas de Kolmogorov-Smirnov; T de Student; Anova y test de Friedman. Participaron en total 223 niños. Se observó que el 89,7% de los niños evaluados eran susceptibles al cinetosis. Hubo una diferencia significativa en la comparación de la susceptibilidad al cinetosis entre los sexos, en la cual las niñas eran más susceptibles que los niños (p=0,001). En cuanto a los grupos de edad, no hubo significación estadística. Los niños de 12 años fueron más susceptibles al cinetosis. Hubo una diferencia en las respuestas informadas por los niños y los padres sobre la susceptibilidad de los niños al cinetosis.

ABSTRACT Motion sickness is characterized by intolerance to movement, resulting from a sensory conflict between the visual, proprioceptive and vestibular systems. In the child population, motion sickness is frequent, but the difficult diagnosis ends up underestimating the prevalence in this specific group. Pediatric vestibular changes are of great importance in child development. The objective was to analyze the susceptibility to motion sickness in children and to verify possible associated factors, as well as to identify differences in the responses when compared to sex, age group and parents' self-perception. This is a cross-sectional study. The consecutive convenience sample consisted of children of both sexes, aged between eight and eleven years old. The motion sickness questionnaire short form (MSSQ) was applied individually with each child. Statistical analysis was performed using the SPSS Version v.21 (Chicago: SPSS). A significance level of 0,005 was adopted. Kolmogorov-Smirnov, Student's T, Anova and Friedman's were the statistical tests used. In total, 223 children were analyzed. 89.7% of the sample was susceptible to motion sickness. There was a significant difference in the comparison of susceptibility to motion sickness between genders, with girls being more susceptible, compared to boys (p=0.001). When comparing age groups, there was no statistical significance. Eleven-year-old children were more susceptible to motion sickness. There was a difference in the responses reported by children and parents about the children's susceptibility to motion sickness.

Introduction of Cybersickness / 대한이비인후과학회지

With an introduce of virtual reality (VR) technology, the issue of unpleasant side effect of VR immersion has been raised as “cybersickness.” Although exact mechanism of cybersickness is still elusive, sensory conflict theory has been generally accepted as in classic motion sickness. The absence of expected correlated vestibulo-proprioceptive sensory information during VR experience causes sensory conflict, which leads to dizziness, disorientation, nausea and fatigue. Herein, we review the recent literature to build the conceptual scheme for understanding cybersickness. From the brief description of motions sickness, assessment and management of cybersickness is also outlined.

Effects of Tianxiang capsule on neurotransmitters and hormone level in rats with motion sickness / 国际中医中药杂志

Objective To investigate the effects of Tianxiang capsule on Neurotransmitters and Hormone Level of rats with motion sickness. Methods Male SD rats were randomly divided into six groups, including blank control group, model control group, positive drug control group, low-dose, mid-dose and high-dose Tianxiang capsule groups with the method of random digital table, and every group had 10 mice. Except the normal group, the rats in the other groups were intragastrically pre-administered for 1 hour, and the low, medium and high doses of Tianxiang capsule were 0.91, 1.82, 3.64 g/kg, the positive drug control group was given scopolamine 1 mg/kg, and then the rat motion sickness model was induced by a rotary stimulation device. After the modeling, the feces, urine, standing hair, trembling were immediately observed and recorded, and the halo response index of the rats was calculated. The blood from the heart puncture was taken and the vestibular nucleus were put on the ice. Then, the content of histamine (HIS) in the vestibular nucleus and plasma was detected by ELISA. The expression of plasma cortisol (Cort) and arginine vasopressin (AVP) were measured by radioimmunoassay. Results Compared with the model control group, the motion sickness index of rats with low, medium and high doses of Tianxiang capsule (6.56 ± 2.16, 6.10 ± 1.35, 4.46 ± 2.50 vs. 8.90 ± 2.61) significantly decreased (P<0.05 or P<0.01). The HIS content in the vestibular nucleus (12.70 ± 3.86 μg/L, 11.45 ± 1.57 μg/L, 10.02 ± 1.30 μg/L vs. 17.50 ± 4.82 μg/L) significantly decreased (P<0.05 or P<0.01). The plasma content of HIS (4.24 ± 1.75 μg/L vs. 7.69 ± 3.06 μg/L), Cort (286.90 ± 8.72 ng/ml vs. 329.26 ± 29.04 ng/ml) and AVP (16.54 ± 2.48 pg/ml vs. 22.35 ± 3.08 pg/ml) in the high doses of Tianxiang capsule significantly decreased (P<0.05 or P<0.01). Conclusions The Tianxiang capsule could effectively reduce the motion sickness index of rats with motion sicknes, which might be related to the down-regulation of HIS in Vestibule Nucleus and HIS, Cort and AVP in plasma.

Research progress in vestibular physiological mechanism of motion sickness / 第二军医大学学报

Motion sickness is a physiological disorder induced by abnormal acceleration stimuli during spaceflight, aviation or sailing. It has been confirmed that the vestibular system, as the core for locomotion sensing and acceleration information processing, plays key roles in motion sickness initiation and autonomic symptom development. Although the mechanism of motion sickness is still unclear, there have been new breakthroughs in recent years about the physiological basis of sensory conflict theory and the neural mechanism of autonomic reflex. This paper reviewed the progress in the vestibulo-visuo-proprioception information integration, the involvement of vestibulo-hippocampus and vestibulo-cortex in locomotion information processing, vestibulo-autonomic reflex pathway, vestibular neurotransmitter system and anti-motion sickness drug targets, laying a foundation for promoting the development and application of novel countermeasures for motion sickness.

Safety and efficacy of dimenhydrinate for treatment of motion sickness / 第二军医大学学报

Dimenhydinate, an antihistamine agent, is effective for treating motion sickness and has a value for both civil and military application. We searched PubMed, the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials, EMBASE, CINAHL, Web of Science, BIOSIS Preview for related literatures. In this paper we reviewed the retrieved literatures and discussed the safety and efficacy of dimenhydrinate in the treatment of motion sickness. It was showed that although the first choice for motion sickness was scopolamine, dimenhydrinate was, however, the first choice for nausea and vomiting, which is partly because it can reduce gastric motility during motion sickness-inducing stimuli. Therefore, dimenhydrinate might be the first choice for treating motion sickness combined with vomiting and nausea.

Application of revised MSSQ for seasickness susceptibility evaluation / 第二军医大学学报

Objective To modify the Golding edition of motion sickness susceptibility questionnaire (MSSQ) for seasickness susceptibility evaluation in Chinese male adults and to establish the corresponding grading criteria. Methods Totally 121 participants were selected to complete the MSSQ. The MSS indices were calculated by the following methods: the MSSQ-R1 included the common motion items of MSSQ in the questionnaire and omitted the correction factor in the formula. Based on MSSQ-R1. MSSQ-R2 and R3 formula had increased weights for vomiting and nausea score. The MSS grading criteria were set based on the percentiles of each MSS indices. All subjects underwent a voyage at sea under 3-4 grade sea condition. Seasickness was assessed by using Graybiel rating scales and the efficacy of the modified MSS indices was evaluated. Results The retest reliability was 0. 85. As for criterion validity, each MSS index was positively correlated with Graybiel score (P<0. 001), with MSSQ R3 having the highest correlation coefficient. The correlation of MSSQ R3 adult index (MSSQ R3 Adt) was also higher than MSSQ-R3 itself (0. 43 vs 0. 39). The Graybiel score of highly susceptible subjects as judged by MSSQ-R3 criteria were significantly higher than those of slightly (P<0. 01) and moderately susceptible (P<0. 05) ones. The Graybiel score of highly and moderately susceptible subjects as judged by MSSQ-R3-Adt criteria were significantly higher than that of slightly susceptible ones (P

Scopolamine tablet and transdermal agent in combination with domperidone for prevention and treatment of seasickness / 第二军医大学学报

Objective To observe the preventive and therapeutic effects of scopolamine tablet and transdermal agent in combination with domperidone for seasickness in different voyage distances and sea state conditions. Methods A total of 236 participants were selected and batched for three trials (Trial 1: 80 sea miles voyage. 1-2 degree of sea state; Trial 2; 80 sea miles voyage. 3-4 degree of sea state; and Trial 3: 200 sea miles voyage. 3-4 degree of sea state). The motion sickness susceptibility questionnaire (MSSQ) was used to assess the seasickness susceptibility. The participants in each trial were divided into comprehensive medication group (CMG) receiving low dose oral and transdermal scopolamine in combination with oral domperidone. prophylactic medication group (PMG) receiving low dose oral and transdermal scopolamine, and placebo control group (PCG) receiving oral vitamine C Motion sickness symptoms were evaluated by using Wiker rating scales. Results In trial 1. the Wiker scores and moderate seasickness incidence in the CMG and FMG were significantly lower than those in the PCG (P0. 05). In trial the Wiker scores were significantly lower in the CMC than in the PCG (P0. 05). In trial 3 the Wiker scores were significantly lower in the CMG than in the PCG (P0. 05). Conclusion low dose oral and transdermal scopolamine in combination with oral domperidone can alleviate seasickness symptoms and decrease incidence of severe seasickness during long-term voyage at sea.

Clinical study of motion sickness with Helicobacter pylori infection and eradication / 中国基层医药

Objective To study the helicobacter pylori(HP)infection and incidence of motion sickness,and observe the improment of motion sickness symptoms of motion sickness group after eradication of helicobacter pylori. Methods Random drawing from chronic gastritis of digestive diseases outpatient spot in the crowd of 765 people, which were investigated through the age,job title,medical history,symptoms of motion sickness and 14 C -UBT test. 153 cases of motion sickness with 14 C -UBT test positive were observed before and after helicobacter pylori eradication of the change of motion sickness symptoms by using quadruple therapy in patients with helicobacter pylori eradication, results were analyzed according to the survey.Results 765 people,384 cases HP positive,HP total positive rate 50.20%.motion sickness occurred in 213 cases,motion sickness was 153 cases HP positive,HP positive rate 71.83%(153 /213);Without HP positive,231 cases of motion sickness,positive rate of motion sickness group were 41.85%(231 /552),which were similar between the two groups with statistically significant(χ2 =55.27,P <0.05). In the HP positive and carsick 153 cases,76 cases of using quadruple therapy for the eradication of helicobacter pylori,and motion sickness symptoms improved were 11 cases 1 years later.The eradication of helicobacter pylori was not used in 77 cases,in which motion sickness symptoms improved for 2 cases 1 year later.And the comparative difference was statistically significant(χ2 =6.94,P <0.05).Conclusion HP infection has certain correlation with the incidence of motion sickness,the eradication of helicobacter pylori may be beneficial to improve the symptoms of motion sickness.

Therapeutic Properties of Zingiber officinale Roscoe: A Review.

Aims: Ginger, a rhizome of Zingiber officinale Roscoe (Fam. Zingiberaceae), has been widely used as a spice to enhance the flavor of food and beverages and for medical purposes in various diseases. Methodology: The review covers the databases and articles published between 2002- 2013 via Medline and published papers on the Internet from Scientific Information Database, MagIran and Irandoc. Literature searches were performed to identify all the researches on ginger for treatment properties. Results: The researchers conducted on ginger in medical field were about nausea and vomiting in pregnancy, contraceptive pills nausea, dysmenorrhea, motion sickness, cough, ventilator associated pneumonia, rheumatic diseases, antibacterial and antiviral effects, nausea and vomiting due to chemotherapy, spermatogenesis, anti-hyperlipidemia anti-inflammatory, diabetes nephropathy and postoperative nausea and vomiting. Clinical trials about ginger were mostly to prevent and treat nausea and vomiting during pregnancy. Conclusion: According to the published articles, ginger is an extraordinary herb and more detailed clinical trials using ginger are recommended for further studies in future.

Improvement of Graybiel's scoring system for grading of motion sickness in hot-humid environment / 第二军医大学学报

Objective: To observe the possible bias in Graybiel's scoring system caused by change of complexion and sweating for grading of motion sickness in hot-humid environment, so as to make improvement to the system. Methods: A total of 567 subjects received Collis rotating chair tests in room temperature environment, hot temperature environment, and hot-humid environment. The severity of motion sickness was graded by Graybiels scoring system. Paired designwas done among 4 groups (calculated with pallor and sweating, no pallor, no sweating, and no pallor no sweating). Results: Graybiel's scores were significantly different under3 different environments, either calculated with pallor and sweating, or without pallor, without sweating, or without both (P<0.01). The corresponding grades of Graybiel's score were also significantly different when calculated without sweating and without both pallor and sweating, but not when calculated without pallor. Conclusion: Our findings suggest that changes of complexion should not be considered when calculating Graybiel's score in hot-humid environment so as to simplify the evaluating process.

Progress on drugs for motion sickness / 国际药学研究杂志

Motion sickness causes great inconvenience, especially for military operations such as navigation, aviation and other activities. With the rapid development of transportation, the incidences of motion sickness are on the rise, directly causing noncombat loss, seriously reducing the operational capability of military personnel, and affecting people's travel and health at the same time. So it is of great significance for the research of antimotion sickness drugs. This article reviews the mechanism, prediction and the treatment drugs for motion sickness.

A kind of exponential model of seasickness habituation / 医用生物力学

Objective To provide a quantitative analysis tool by building a mathematical model of seasickness habituation to make adaptive training plans scientifically for anti-seasickness purpose. Methods Based on the regular pattern of seasickness habituation, an exponential model of motion sickness incidence (MSI) was established to extract such seasickness habituation parameters as anti-motion sickness incidence (AMSI) and anti-motion sickness rate (μ) through making the seasickness habituation data fitting into the corresponding training, and the effects of AMSI and μ on MSI was also simulated. Results The data from two marine adaptive trainings were well fitted with the MSI model, and the fitting results of AMSI and μ were 0.87 and 0.048 for intermittent training, or 0.81 and 0.34 for continuous training. Effects of seasickness habituation training would be enhanced by increasing the value of AMSI and μ. Conclusions The present model of MSI is suitable for evaluating the effect of training on anti-seasickness and making the optimal strategy for such seasickness habituation training.

Progress on drugs for motion sickness / 国际药学研究杂志

Motion sickness causes great inconvenience,especially for military operations such as navigation ,aviation and other activities. With the rapid development of transportation,the incidences of motion sickness are on the rise,directly causing non-combat loss,seriously reducing the operational capability of military personnel,and affecting people's travel and health at the same time. So it is of great significance for the research of anti-motion sickness drugs. This article reviews the mechanism,prediction and the treatment drugs for motion sickness.

Systematic review of the effect of dried ginger powder on improvement of nausea and vomiting associated with early pregnancy or motion sickness / 한국영양학회지

PURPOSE: Ginger (Zingiber officinale) has been widely used as an antiemetic agent. This systematic review was aimed at evaluation of the effect of dried ginger powder supplementation on improvement of nausea and vomiting associated with early pregnancy or motion sickness. METHODS: We searched Pubmed, Cochrane, Science Direct, and KISS (Korean studies Information Service System) using keywords such as ginger or Zingiber officinale in combination with nausea, vomiting, motion sickness, or pregnancy, published in March 2013. RESULTS: The strength of the evidence was evaluated on the selected 12 RCTs (randomized controlled trials). Eleven trials including 2,630 subjects showed that supplementation with dried ginger powder resulted in significant improvement of nausea or vomiting related to early pregnancy or motion sickness. Among the nine studies including 809 women in early pregnancy before 20 weeks of gestation, ginger supplementation was superior to placebo in five studies (n = 305), and as effective as positive control (vitamin B6 or dimenhydrinate) in four studies (n = 504). Ginger intake significantly reduced the episodes or severity of vomiting related to motion sickness compared to placebo or showed the same effect as several antiemetic drugs in two studies (n = 1,821). CONCLUSION: Our findings added evidence indicating that ginger powder supplements might improve the symptoms of nausea or vomiting related to early pregnancy or motion sickness without significant adverse events.

Research progress on motion sickness / 军事医学

This paper reviews the etiology , pathogenesis ,prediction and evaluation and other related aspects of motion sickness in order to contribute to further research on motion sickness and to proride the theorotic basis for prevention .